Men at Higher Risk for Mild Memory Loss Than Women

ST. PAUL, Minn. – Men may be at higher risk of experiencing mild cognitive impairment (MCI), or the stage of mild memory loss that occurs between normal aging and dementia, than women, according to a study published in the January 25, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.

“These results are surprising, given that women generally have higher rates of dementia than men,” said study author R.O. (Rosebud) Roberts, MB ChB, MS, of the Mayo Clinic in Rochester, Minn., and a member of the American Academy of Neurology. “The risk of MCI in men and women combined was high in this age group of elderly persons. This is disturbing given that people are living longer, and MCI may have a large impact on health care costs if increased efforts at prevention are not used to reduce the risk.”

For the study, a group of 1,450 people from Olmsted County, Minn., between the ages of 70 and 89 and free of dementia at enrollment underwent memory testing every 15 months for an average of three years. Participants were also interviewed about their memory by medical professionals. By the end of the study period, 296 people had developed MCI.

The study found that the number of new cases of MCI per year was higher in men, at 72 per 1,000 people compared to 57 per 1,000 people in women and 64 per 1,000 people in men and women combined. MCI with memory loss present was more common at 38 per 1,000 people than MCI where memory loss was not present, which affected 15 per 1,000 people. Those who had less education or were not married also had higher rates of MCI.

“Our study suggests that risk factors for mild cognitive impairment should be studied separately in men and women,” said Roberts.

Another finding of interest in the study showed that among people who were newly diagnosed with MCI, 12 percent per year were later diagnosed at least once with no MCI, or reverted back to what was considered “cognitively normal.” Roberts said the majority of people with MCI, about 88 percent per year, continue to have MCI or progress to dementia.

The study was supported by the National Institutes of Health, the Robert Wood Johnson Foundation, the Robert H. and Clarice Smith and Abigail van Buren Alzheimer’s Disease Research Program and was made possible by the Rochester Epidemiology Project.

The American Academy of Neurology, an association of 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

Released: 1/17/2012

Source: American Academy of Neurology

Related Link:

http://www.newswise.com/articles/study-men-at-higher-risk-for-mild-memory-loss-than-women

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‘Dabbling’ in Hard Drugs in Middle Age Linked to Increased Risk of Death

Newswise — Young adults often experiment with hard drugs, such as cocaine, amphetamines and opiates, and all but about 10 percent stop as they assume adult roles and responsibilities. Those still using hard drugs into their 50s are five times more likely to die earlier than those who do not, according to a new study by University of Alabama at Birmingham researchers published online Jan. 27, 2012, in the Journal of General Internal Medicine.

According to the National Survey on Drug Use and Health, 9.4 percent of Americans ages 50-59 and 7 percent of adults ages 35-49 reported use of a drug other than marijuana sometime in the past year. The study’s lead author, Stefan Kertesz, M.D., associate professor in the UAB Division of Preventive Medicine. and colleagues attempted to discover if lifelong hard-drug use shortens lifespan to better enable primary-care doctors to advise patients who use drugs recreationally.

“While government guidelines have not endorsed screening for drugs in primary care, many doctors are challenged when they discover patients continue to dabble with them,” Kertesz says. “In primary-care practice, we often hear from stable patients who report using some cocaine, irregularly, perhaps on weekends. It’s an underappreciated but very common situation. The typical question physicians have to ask is ‘If this patient doesn’t have addiction, what advice can I give other than noting that it’s unwise to break the law?’ After all, we are supposed to be doctors, not law enforcement.”

Kertesz and a research team from other universities looked at data from the Coronary Artery Risk Development in Young Adults Study for their analysis. CARDIA, funded by the National Heart, Lung and Blood Institute, is a long-term research project involving more than 5,000 black and white men and women from Birmingham, Chicago, Minneapolis and Oakland, designed to examine the development and determinants of cardiovascular disease and its risk factors. Participants ages 18-30 were recruited and followed from 1985 to 2006.

The research team looked specifically at the reported use of “hard drugs” by 4,301 of the CARDIA participants. They compared people who stopped drug use early to those who continued and calculated the likelihood of premature death among these groups.

“Fourteen percent of the people in the study reported recent hard-drug use at least once, and of these, half continued using well into middle age,” Kertesz says. “But, most of the drug users in our study were not addicts. They were dabblers who used just a few days a month.”

Kertesz and his colleagues found that older hard-drug users were more likely to report being raised in economically challenged circumstances in a family that was unsupportive, abusive or neglectful. The team also found that those who were heavy drug users into young adulthood and continued at lower levels into middle age were roughly five times more likely to die than persons who didn’t use drugs.

“We can’t assume that drugs caused death, as in an overdose,” he says. “Rather what we found is that middle-age adults who continue to dabble in hard drugs represent a group that is at risk of bad outcomes — which could include death from trauma, heart disease or other causes that are not a direct result of their drug use — at a higher rate than people who stopped using drugs.”

Kertesz added that the team’s findings are a reminder that people who continue to use drugs are potentially quite vulnerable. They often have grown up under economic and psychosocial stress from childhood onward. They continue to smoke and drink and they remain at elevated risk of premature death.

“Based on the data we hope to offer better advice to primary-care doctors struggling with the rising tide of drug-taking by adults who have not left behind many of the bad habits they learned in young adulthood,” he says.

Study co-authors include Yulia Khodneva, M.D., Monika Safford, M.D., and Joseph Schumacher, Ph.D., UAB Division of Preventive Medicine; Jalie Tucker, Ph.D., UAB School of Public Health; Joshua Richman, M.D., Ph.D., UAB Department of Surgery; Bobby Jones, Ph. D., Department of Statistics, Carnegie Mellon University; and Mark J. Pletcher, M.D., departments of Epidemiology & Biostatistics and Medicine, University of California, San Francisco.

Released: 1/27/2012

Source: University of Alabama at Birmingham

Related Link:

http://newswise.com/articles/dabbling-in-hard-drugs-in-middle-age-linked-to-increased-risk-of-death

CT Scans for Dizziness in the ER: Worth the Cost?

Newswise — DETROIT – Performing CT scans in the emergency department for patients experiencing dizziness may not be worth the expense – an important finding from Henry Ford Hospital researchers as hospitals across the country look for ways to cut costs without sacrificing patient care.

According to the Henry Ford study, less than 1 percent of the CT scans performed in the emergency department revealed a more serious underlying cause for dizziness – intracranial bleeding or stroke – that required intervention.

The findings suggest that it may be more cost effective for hospitals to instead implement stricter guidelines for ordering in-emergency department CT scans of the brain and head for patients experiencing dizziness.

“When a patient comes into the emergency department experiencing dizziness, a physician’s first line of defense is often to order a CT scan to rule out more serious medical conditions. But in our experience it is extremely rare that brain and head imagining yields significant results,” says study author Syed F. Ahsan, M.D., a neuro-otologist in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

“It is our hope that our investigation into our own practices will shed light on avenues to run leaner practices within our institution, as well as serve as a model for other health systems.”

The study will be presented Jan. 26 in Miami Beach at the annual Triological Society’s Combined Sections Meeting.

The Henry Ford study was a retrospective review of 1,681 patients with dizziness or vertigo who came into a Detroit metropolitan emergency department between January 2008 and January 2011.

Of those patients, nearly half (810 patients) received a CT scan of the brain and head, but only 0.74 percent of those scans yielded clinically significant results that required intervention. In all, the total cost for the CT scans during the three-year period was $988,200.

The analysis also revealed that older patients and those with a lower income were more likely to receive a CT scan for dizziness when they came into the emergency department.

While dizziness may signal intracranial bleeding or stroke, it is more likely that the cause is due to dehydration, anemia, a drop in blood pressure with standing (orthostatic hypotension), problems or inflammation in the inner ear such as benign paroxysmal postional vertigo, labyrinthitis or meniere’s disease, or vestibular neuritis.

And, Dr. Ahsan notes, in previous studies it has been well documented that CT scans are not very effective in detecting stroke or intracranial bleeding in the acute (emergency room) setting.

Ultimately, the study shows that there is potential for cost savings by creating and implementing stronger guidelines to determine when it is medically necessary for patients with dizziness to undergo CT imaging in the emergency department.

Funding: Henry Ford Hospital

Along with Dr. Ahsan, Henry Ford study co-authors are Mausumi N. Syamal, M.D., and Kathleen Yaremchuk, M.D.

Released:  1/26/2012

Source: Henry Ford Health System

Related Link:

http://www.newswise.com/articles/ct-scans-for-dizziness-in-the-er-worth-the-cost

To Turn Up the Heat in Chilies, Just Add Water!

Newswise — Biologists have learned in recent years that wild chilies develop their trademark pungency, or heat, as a defense against a fungus that could destroy their seeds. But that doesn’t explain why some chilies are hot and others are not.

New research provides an answer: Hot chilies growing in dry areas need more water to produce as many seeds as non-pungent plants, but the Fusarium fungus is less of a threat in dryer environments so chilies in those areas are less likely to turn up the heat. In wetter regions, where Fusarium thrives, wild chilies build up their reserves of spicy capsaicin in self-defense.

“Despite the reduced benefit of pungency in dry environments, hot plants still occur there, as does the deadly fungus. That suggests that the greater presence of non-pungent plants that produce substantially more seeds is the result of a fitness-based tradeoff,” said David Haak, lead author of a paper describing the research published Wednesday (Dec. 21) inProceedings of the Royal Society B. The Royal Society is the United Kingdom’s academy of science.

Haak, a post-doctoral researcher at Indiana University, conducted the research as part of his doctoral work at the University of Washington. Co-authors of the paper are Leslie McGinnis of the University of Michigan, who did the work while a UW undergraduate; Douglas Levey of the University of Florida and Joshua Tewksbury, a UW biology professor who leads the research group.

The scientists examined pungency differences by comparing the proportion of pungent plants with that of non-pungent plants in 12 populations of wild chilies in southeastern Bolivia along a 185-mile line that gradually progressed from a relatively dry region to a wetter region. They conducted plant censuses in focal populations five times between 2002 and 2009, and tagged plants in each census so they could determine new seedlings the next time.

They found that, starting in the dryer northeast part of the section, 15 to 20 percent of the plants had pungent fruit, and pungency increased along the line toward the wetter southwest, where they never found a single plant that did not produce pungent fruit.

They also selected three populations of chili plants that each produced both pungent and non-pungent fruit and spanned the range of rainfall and pungency differences. They then grew seeds from those plants in the UW Botany Greenhouse to examine what affect water availability had on pungency.

The 330 plants that resulted from those seeds were grown under identical conditions until they reached their first flowering, then were separated into two groups – one that received plenty of water and one that was stressed by receiving only the amount of water available to plants in the driest area of Bolivia from which seeds were taken.

The scientists found that under water-stressed conditions, non-pungent plants produced twice as many seeds as pungent plants. That suggests the pungent plants trade some level of fitness for protection from the Fusarium fungus, Haak said.

The researchers determined the pungent plants have developed a reduced efficiency in water use, so in dryer areas they produce fewer seeds and are more limited in reproduction. In wetter areas, non-pungent plants are at a reproductive disadvantage because they are much more likely to have their seeds attacked by the fungus.

“It surprised us to find that the tradeoff to produce capsaicin in pungent plants would involve this major physiological process of water-use efficiency,” Haak said.

He noted that over the entire range, 90 to 95 percent of the chili fruits had some level of fungal infection, and pungent plants were better able to defend themselves.

The research was funded by grants from the National Science Foundation; the National Geographic Society; Sigma Xi, the scientific research society; and the UW Department of Biology.

Released: 12/20/2011

Source: University of Washington

Related Link:

http://www.newswise.com/articles/to-turn-up-the-heat-in-chilies-just-add-water

Cohabitating Valentines Are Happier Than Wedded Couples

Newswise — ITHACA, N.Y. — When it comes to the well-being of married versus cohabitating Valentines, wedded couples experience few advantages in psychological well-being and social ties, according to a new study at Cornell University.

The study, “Reexamining the Case for Marriage: Union Formation and Changes in Well-being,” is being published in the February issue of the Journal of Marriage and Family(available online: http://bit.ly/xL4t9U).

“We found that differences between marriage and cohabitation tend to be small and dissipate after a honeymoon period. Also while married couples experienced health gains – likely linked to the formal benefits of marriage such as shared health care plans – cohabiting couples experienced greater gains in happiness and self-esteem. For some, cohabitation may come with fewer unwanted obligations than marriage and allow for more flexibility, autonomy and personal growth,” said Kelly Musick, associate professor of policy analysis and management at Cornell’s College of Human Ecology, who co-authored the study with sociologist Larry Bumpass of the University of Wisconsin-Madison.

“Marriage has long been an important social institution, but in recent decades western societies have experienced increases in cohabitation, before or instead of marriage, and increases in children born outside of marriage,” said Musick. “These changes have blurred the boundaries of marriage, leading to questions about what difference marriage makes in comparison to alternatives.”

Previous research has sought to prove a link between marriage and well-being, but many studies compared marriage to being single, or compared marriages and cohabitations at a single point in time.

This study compares marriage to cohabitation while using a fixed-effects approach that focuses on what changes occur when single men and women move into marriage or cohabitation and the extent to which any effects of marriage and cohabitation persist over time.

The researchers used a sample from the National Survey of Families and Households of 2,737 single men and women, 896 of whom married or moved in with a partner over the course of six years. The study focused on key areas of well-being, considering questions on happiness, levels of depression, health and social ties.

“Compared to most industrial countries, America continues to value marriage above other family forms,” concluded Musick. “However our research shows that marriage is by no means unique in promoting well-being and that other forms of romantic relationships can provide many of the same benefits.”

The study was funded in part by the National Institute of Child Health and Human Development and the Office of Behavioral and Social Sciences.

Released: 1/24/2012

Source:  Cornell University

Related Link:

http://newswise.com/articles/cohabitating-valentines-are-happier-than-wedded-couples-finds-study

Museum to Visitors: Please Do Touch, for Scientific Purposes

Photo Credit: The Walters Art Museum, Modest Venus, or Venus Pudica, a 10.5-inch bronze statuette cast around 1500 by an anonymous Italian artist, is one of the pieces replicated for museum goers to caress for science at an exhibition in Baltimore.

Newswise — It’s the first rule at any art museum: Do not touch the artifacts. Except at this museum and at this one time.

At the “Touch and the Enjoyment of Sculpture: Exploring the Appeal of Renaissance Statuettes” exhibition — at the Walters Art Museum in Baltimore through April 15 — visitors are invited to disregard that decree and to hold, stroke and even caress the pieces.

In fact, handling the objects d’arts — replicas of famous 16th century statuettes held by the Walters — is one of the reasons for the exhibition, explains neuroscientist Steven Hsiao, a researcher at the Johns Hopkins Brain Science Institute. The institute is partnering with the Walters on the show, the fourth in a series of projects between the museum and Johns Hopkins.

“We’re challenging people to think about why physical contact with works of art can be so satisfying,” says Hsiao, whose work includes exploring many aspects of humans’ sense of touch. “In fact, as people browse the exhibition, we will be asking them to react to what they are seeing and feeling.”

The installation incorporates 12 works of art from the Walters collection, along with 22 replicas for visitors to touch and rate, providing data for ongoing research.

The project melds the research interests of Hsiao, who specializes in many facets of touch, and those of Joaneath Spicer, the Walters’ curator of Renaissance and Baroque art, who studies the Renaissance penchant for collecting and commissioning small statuettes and other luxury goods that were satisfying to touch and handle.

But the special appeal of this exhibition lies in the opportunity to join in comparative experiments with the statuettes (well, the replicas, actually).

“We’ll be asking visitors to handle them and to tell us what sculptures they prefer and to rate how they like sculptures that have been modified in their shape and texture. This exhibition allows us to dissect why some objects feel better than others” Hsiao says.

Visitors will register these preferences, and other reactions, on Apple iPads, and visitors will be able to see a dynamic display of their responses. The data will be used in Hsaio’s and Spicer’s research on tactile aesthetics. (Visitors will not be handling the original 16th century artwork; they will only be permitted to touch replica art exclusively fashioned for the show.)

The Walters Art Museum is open from 10 a.m. to 5 p.m. Wednesdays through Sundays and is located at 600 North Charles St. in Baltimore.

Related links:
Steven Hsiao:
http://neuroscience.jhu.edu/StevenHsiao.php

The Johns Hopkins Brain Science Institute:
http://www.hopkinsmedicine.org/brainscience/

The Walters Art Museum:
http://thewalters.org/eventscalendar/eventdetails.aspx?e=2207

Released: Released: 1/23/20

Source: Johns Hopkins

Related Link:

http://newswise.com/articles/museum-to-visitors-please-do-touch-for-scientific-purposes

Sleep Preserves and Enhances Bad Emotional Memories

Photo Credit: UMass Amherst, Based on a recent study that included polysomnography, neuroscientists at UMass Amherst suggest that emotional memories are protected by the brain during sleep.

Newswise — AMHERST, Mass. – A recent study by sleep researchers at the University of Massachusetts Amherst is the first to suggest that a person’s emotional response after witnessing an unsettling picture or traumatic event is greatly reduced if the person stays awake afterward, and that sleep strongly “protects” the negative emotional response. Further, if the unsettling picture is viewed again or a flashback memory occurs, it will be just as upsetting as the first time for those who have slept after viewing compared to those who have not.

UMass Amherst neuroscientists Rebecca Spencer, Bengi Baran and colleagues say this response could make sense from an evolutionary point of view, because it would provide survival value to our ancestors by preserving very negative emotions and memories of life-threatening situations and offer a strong incentive to avoid similar occasions in the future.

“Today, our findings have significance for people with post-traumatic stress disorder, for example, or those asked to give eye-witness testimony in court cases,” Spencer says.

“We found that if you see something disturbing, let’s say an accident scene, and then you have a flashback or you’re asked to look at a picture of the same scene later, your emotional response is greatly reduced, that is you’ll find the scene far less upsetting, if you stayed awake after the original event than if you slept. It’s interesting to note that it is common to be sleep-deprived after witnessing a traumatic scene, almost as if your brain doesn’t want to sleep on it.” The study is reported in the current issue of the Journal of Neuroscience.

In their experiments involving 68 healthy female and 38 male (total 106) young adults between 18 and 30 years old, Spencer and colleagues set out to explore, among other ideas, an assumption that the well-known enhancement of memory that occurs during sleep is tied to a change in emotional response to the memory.

Further, in a subset of subjects the neuroscientists used a polysomnograph with electrodes attached to subjects’ scalps as they slept, to investigate whether dreaming or other brain processes that occur during rapid-eye-movement (REM) sleep periods may play a role in the processing of emotions.

In the two-phase experiment, participants were shown pictures on a computer screen and asked to rate each one as sad or happy as well as their own response as calm or excited to each, on a scale of 1-9. The researchers counted sad-happy ratings and calm-excited of 1-3 as negative images and 4-6 as neutral, so each participant’s overall “emotional value” score was unique.

Twelve hours later, participants were shown a mix of new and already viewed pictures and asked whether they had ever seen the picture before and to rate each again on the two scales. They all kept a sleep diary and took a sleep quality index test, as well.

Session timing was arranged so that 82 subjects were assigned either to a Sleep group who saw the first set of pictures late in the day and the second group of pictures after they had slept overnight or to a Wake group, who saw the first set of pictures in the morning and the second set later the same day. To rule out a possible circadian effect on attention, 24 different subjects followed the same routine but with only a 45-minute break between the two phases. Polysomnography data were collected from 25 participants in the Sleep group in their own homes overnight.

Spencer and colleagues found that sleep had significant effects on participants’ memories and feelings. Recognition memory for the pictures was better following sleep compared with wake.

Importantly, the researchers found that contrary to previous assumptions that sleep might soften negative emotional effects of a disturbing event, a period of sleep was associated with participants’ maintaining the strength of their initial negative feelings compared to a period of wakefulness. This suggests that sleep’s effect on memory and emotion are independent, the authors state.

The researchers found no significant relationship between REM sleep time and participants’ accuracy in recalling whether they had seen a picture in both the first and second phases of the study. As such, how sleep protects the emotional response and the emotional memory are unanswered questions. “Sleep may, in fact, be protective of the emotional salience of a stimulus just as sleep protects the emotional memory,” the authors point out.

This work was supported by the National Institutes of Health and the UMass Amherst Commonwealth Honors College.

Released: 1/16/2012

Source:  University of Massachusetts Amherst

Related Link:

http://www.newswise.com/articles/sleep-preserves-and-enhances-bad-emotional-memories

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